What Is Cooling agent WS-23?N,2,3-trimethyl-2-isopropylbutanamide

Cooling agent WS-23 (N,2,3-trimethyl-2-isopropylbutanamide, CAS 51115-67-4) is a synthetic carboxamide-based high-efficiency cooling agent. Its structure is unrelated to menthol, yet it produces an “intense, long-lasting, and pure” cooling sensation in the mouth and throat, without burning, numbness, or bitter aftertaste.What Is Cooling agent WS-23?N,2,3-trimethyl-2-isopropylbutanamide

1. Physical and Chemical Properties:
Appearance: White crystalline powder, melting point 60-64 ℃, flash point 131.6 ℃
Purity: ≥99% (GC)
Solubility: Water <0.1%, easily soluble in ethanol, propylene glycol, oils and most flavor carriers
Thermal stability: Almost no decomposition after baking at 200 ℃, suitable for high-temperature processes such as baking and puffing.
Cooling sensation intensity: Approximately 1.5 times that of menthol, lasting 10-30 min; threshold is only 200 ppb (oral strip method)What Is Cooling agent WS-23?N,2,3-trimethyl-2-isopropylbutanamide

2. Recommended Dosage:
Hard candy, compressed tablets: 50-150 ppm, added later with flavorings, avoid high temperature and prolonged heating;
Chewing gum: 750-3000 ppm, mixed with gum base and flavorings, provides the longest-lasting cooling sensation;
Jelly/Gummy candy: 30-80-200 ppm, dissolved in the aqueous phase and added while hot (<80 ℃);
Carbonated beverages/functional water: 10-30-50 ppm, first dissolved in 5-10 times the amount of ethanol or propylene glycol, then added to the syrup;
Ice cream/yogurt: 20-50-100 ppm, added at ≤40 ℃ during the later stages of ingredient mixing to prevent volatilization;
Baking (biscuits, wafers): 30-80-200 ppm, use microencapsulated type or increase the dosage by 10-20%;
Solid beverages/effervescent tablets: 50-150-300 ppm, dry mixed with citric acid and sodium bicarbonate;
Tobacco/e-cigarette liquid: 100-500-1000 ppm, dissolved in PG/VG (70-80 ℃) and then mixed;
Oral care (toothpaste, mouthwash): 300-800-1500 ppm It is pre-dissolved with sorbitol and glycerin before being incorporated into the aqueous phase;What Is Cooling agent WS-23?N,2,3-trimethyl-2-isopropylbutanamide

3. Key points for use:
Pre-dissolution: First, melt it with 5-10 times the amount of ethanol, propylene glycol, or oil at 55°C, then add it to the system to avoid localized supercooling and crystallization.
Synergy: When compounded with menthol, menthone, lemon flavor, etc., it can reduce the amount of menthol used by 30-50%, while achieving a dual cooling sensation of “impact + long-lasting”.
Temperature: Aqueous system ≤75℃; for prolonged high temperatures (>15min), use the microencapsulated type or increase the dosage by 10-20%.
Storage: Store in a sealed container, at ≤25℃, and in a dry place away from light; prolonged exposure can easily lead to sublimation and clumping.

Due to its “odorless, non-bitter, high cooling sensation, and high-temperature resistance” characteristics, WS-23 has been widely used in the development of new products such as sugar-free chewing gum, functional water, baked goods, and e-cigarettes, making it an ideal cooling ingredient to replace or supplement menthol.

What Is Cooling agent WS-23?N,2,3-trimethyl-2-isopropylbutanamide